Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI
نویسندگان
چکیده
منابع مشابه
Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade.
Diverse forms of injury cause proximal tubular cholesterol accumulation. However, underlying mechanisms in general, and those involved with ATP depletion injury in particular, remain poorly defined. To help elucidate this issue, cholesterol homeostasis and its determinants were assessed after partial ATP depletion states. Serum-exposed HK-2 cells were subjected to mild ATP depletion, induced by...
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متن کاملProximal Tubular Cholesterol Loading following Mitochondrial, but Not Glycolytic, Blockade
Background: Diverse forms of injury cause proximal tubular cholesterol accumulation. However, underlying mechanisms, in general, and those involved with ATP depletion injury, in particular, remain poorly defined. To help elucidate this issue, cholesterol homeostasis and its determinants were assessed following partial ATP depletion states. Methods: Serumexposed HK-2 cells were subjected to mild...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2016
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2015020177